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You may be familiar with these kinds of changes due to knowledge of, or experience with, cervical precancer. Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review. The types of changes that lead to anal precancer are also found in the cervix, vagina, vulva and penis. Anal cancer includes HPV infection as a precursor to the disease. Anal cancer is defined as cancer arising from the squamous epithelium of the anus, making it distinct from colorectal treatment of anal intraepithelial neoplasia.